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Clin Nutr. 2021 Oct;40(10):5391-5398. doi: 10.1016/j.clnu.2021.08.014. Epub 2021 Aug 24.
3
Reduced MIP-1β as a Trait Marker and Reduced IL-7 and IL-12 as State Markers of Anorexia Nervosa.MIP-1β降低作为神经性厌食症的特质标志物,IL-7和IL-12降低作为神经性厌食症的状态标志物。
J Pers Med. 2021 Aug 20;11(8):814. doi: 10.3390/jpm11080814.
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Zinc as an adjunct to antidepressant medication: a meta-analysis with subgroup analysis for different levels of treatment response to antidepressants.锌作为抗抑郁药物的辅助治疗:一项荟萃分析,进行了亚组分析,以评估对不同水平抗抑郁药物治疗反应的影响。
Nutr Neurosci. 2022 Sep;25(9):1785-1795. doi: 10.1080/1028415X.2021.1888205. Epub 2021 Feb 28.
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A comparative meta-analysis of the prevalence of exercise addiction in adults with and without indicated eating disorders.一项针对有或无特定进食障碍的成年人中运动成瘾患病率的比较性荟萃分析。
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当前和康复神经性厌食症患者的营养摄入和饮食炎症潜能。

Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa.

机构信息

Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.

Division of Psychology and Mental Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK.

出版信息

Nutrients. 2021 Dec 9;13(12):4400. doi: 10.3390/nu13124400.

DOI:10.3390/nu13124400
PMID:34959952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8708616/
Abstract

Anorexia nervosa (AN) is characterised by disrupted and restrictive eating patterns. Recent investigations and meta-analyses have found altered concentrations of inflammatory markers in people with current AN. We aimed to assess nutrient intake in participants with current or recovered AN, as compared to healthy individuals, and explore group differences in dietary inflammatory potential as a possible explanation for the observed alterations in inflammatory markers. We recruited participants with current AN ( = 51), those recovered from AN ( = 23), and healthy controls ( = 49). We used the Food Frequency Questionnaire (FFQ), to calculate a Dietary Inflammatory Index (DII) score and collected blood samples to measure serum concentrations of inflammatory markers. In current AN participants, we found lower intake of cholesterol, compared to HCs, and lower consumption of zinc and protein, compared to HC and recovered AN participants. A one-way ANOVA revealed no significant group differences in DII score. Multivariable regression analyses showed that DII scores were significantly associated with tumour necrosis factor (TNF)-α concentrations in our current AN sample. Our findings on nutrient intake are partially consistent with previous research. The lack of group differences in DII score, perhaps suggests that diet is not a key contributor to altered inflammatory marker concentrations in current and recovered AN. Future research would benefit from including larger samples and using multiple 24-h dietary recalls to assess dietary intake.

摘要

神经性厌食症(AN)的特征是饮食模式紊乱和受限。最近的调查和荟萃分析发现,当前患有 AN 的人群的炎症标志物浓度发生了改变。我们旨在评估当前患有 AN 或已康复的患者与健康个体的营养摄入量,并探讨膳食炎症潜能的组间差异,作为解释观察到的炎症标志物变化的可能原因。我们招募了当前患有 AN 的参与者(n = 51)、从 AN 中康复的参与者(n = 23)和健康对照组(n = 49)。我们使用食物频率问卷(FFQ)来计算膳食炎症指数(DII)评分,并采集血液样本来测量炎症标志物的血清浓度。在当前患有 AN 的参与者中,与 HC 相比,他们的胆固醇摄入量较低,与 HC 和已康复的 AN 参与者相比,锌和蛋白质的摄入量也较低。单因素方差分析显示,DII 评分在各组之间没有显著差异。多变量回归分析表明,在我们的当前 AN 样本中,DII 评分与肿瘤坏死因子(TNF)-α浓度显著相关。我们关于营养摄入量的发现部分与之前的研究一致。DII 评分在各组之间没有差异,这可能表明饮食不是当前和已康复的 AN 中炎症标志物浓度改变的关键因素。未来的研究将受益于纳入更大的样本量和使用多个 24 小时膳食回忆来评估膳食摄入量。