Han Feng-Ying, Song Xiao-Yu, Chen Jing-Jie, Yao Guo-Dong, Song Shao-Jiang
School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Steroids. 2018 Dec;140:125-130. doi: 10.1016/j.steroids.2018.09.014. Epub 2018 Oct 5.
Timosaponin AIII, a major steroidal saponin found in Anemarrhena asphodeloides Bge., which has been widely used as anti-pyretic, anti-diabetic, anti-inflammatory, anti-platelet aggregator and anti-depressant agents in traditional Chinese medicine. Recent pharmacological study showed that timosaponin AIII had potent cytotoxicity, which was potential to be developed as an anticancer agent, however the molecular mechanism underlying the anticancer activity has not been fully elucidated. This review aims to give a systematic summary of the study of timosaponin AIII to reveal its anti-tumor activities by investigating invasion and migration, apoptosis, autophagy and reversing multi-drug resistance. Furthermore, we also make an overview of the mechanisms identified till now. These meaningful findings may provide novel insights on exploiting timosaponin AIII as a new anti-tumor agent.
知母皂苷AIII是知母中发现的一种主要甾体皂苷，在传统中药中已被广泛用作解热、抗糖尿病、抗炎、抗血小板聚集和抗抑郁剂。最近的药理学研究表明，知母皂苷AIII具有强大的细胞毒性，有开发成为抗癌剂的潜力，然而其抗癌活性的分子机制尚未完全阐明。本综述旨在对知母皂苷AIII的研究进行系统总结，通过研究侵袭和迁移、凋亡、自噬以及逆转多药耐药性来揭示其抗肿瘤活性。此外，我们还概述了目前已确定的机制。这些有意义的发现可能为将知母皂苷AIII开发为新型抗肿瘤药物提供新的见解。
