Division of Biomedical Engineering, Human Biology Department, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
Cardiovascular Research Unit, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
J Mech Behav Biomed Mater. 2019 Jan;89:217-226. doi: 10.1016/j.jmbbm.2018.09.025. Epub 2018 Sep 18.
The meniscus is a complex and frequently damaged tissue which requires a substitute capable of reproducing similar biomechanical functions. This study aims to develop a synthetic meniscal substitute that can mimic the function of the native meniscus. Medical grade silicones reinforced with nylon were fabricated using compression moulding and evaluated for mechanical and tribological properties. The optimal properties were obtained with tensile modulus increased considerably from 10.7 ± 2.9 MPa to 114.6 ± 20.9 MPa while compressive modulus was found to reduce from 2.5 ± 0.6 MPa to 0.7 ± 0.3 MPa. Using a tribometer, the coefficient of friction of 0.08 ± 0.02 was measured at the end of the 100,000 cycles. The developed composite could be an auspicious substitute for the native meniscus and the knowledge gained from this study is useful as it enhances the understanding of a potentially suitable material for meniscal implants.
半月板是一种复杂且经常受损的组织，需要一种能够复制类似生物力学功能的替代品。本研究旨在开发一种能够模拟天然半月板功能的合成半月板替代品。使用压缩成型制造了医用级硅酮增强尼龙，并对其机械和摩擦学性能进行了评估。拉伸模量从 10.7±2.9 MPa 显著增加到 114.6±20.9 MPa，而压缩模量从 2.5±0.6 MPa 降低到 0.7±0.3 MPa，从而获得了最佳性能。使用摩擦磨损试验机，在 100000 次循环结束时测量到的摩擦系数为 0.08±0.02。所开发的复合材料可能成为天然半月板的理想替代品，本研究获得的知识很有用，因为它增强了对潜在适合半月板植入物的材料的理解。
