Wong Jordan, Wiseman Sam M
a Department of Surgery, St. Paul's Hospital and University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
Expert Rev Endocrinol Metab. 2015 May;10(3):327-336. doi: 10.1586/17446651.2015.1010515. Epub 2015 Feb 1.
Graves' disease (GD) is an autoimmune disorder in which antibodies directed against thyroid-stimulating hormone receptors leads to thyrotoxicosis. Graves' ophthalmopathy, a condition that occurs in up to half of GD patients, is a cause of significant morbidity and is potentially vision threatening. Three treatment options are equally effective for uncomplicated GD and these include thyroid surgery (thyroidectomy), radioactive iodine thyroid ablation and antithyroid drugs. However, recent practice surveys suggest that surgery is the least favored GD treatment. When GD is complicated by moderate-to-severe Graves' ophthalmopathy, antithyroid drugs and surgery are recommended by current guidelines, and again the preference for thyroid surgery in these cases has remained low. This report aims to review current published data regarding thyroidectomy as a treatment for GD, and in particular, we focus on the effects of thyroidectomy on Graves' ophthalmopathy development and progression.
格雷夫斯病（GD）是一种自身免疫性疾病，针对促甲状腺激素受体的抗体导致甲状腺毒症。格雷夫斯眼病在高达一半的GD患者中出现，是严重发病的原因，并有潜在的视力威胁。三种治疗方案对无并发症的GD同样有效，包括甲状腺手术（甲状腺切除术）、放射性碘甲状腺消融和抗甲状腺药物。然而，最近的实践调查表明，手术是最不受青睐的GD治疗方法。当GD并发中度至重度格雷夫斯眼病时，现行指南推荐使用抗甲状腺药物和手术，而且在这些情况下对甲状腺手术的偏好仍然很低。本报告旨在回顾目前已发表的关于甲状腺切除术作为GD治疗方法的数据，特别是，我们关注甲状腺切除术对格雷夫斯眼病发生和进展的影响。
