Chair and Division of Rheumatology, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Clin Exp Rheumatol. 2019 May-Jun;37(3):429-436. Epub 2018 Oct 8.
We aimed to evaluate the correlation between serum calprotectin and clinical and ultrasonographic (US) variables in early-onset psoriatic arthritis (PsA) and controls with rheumatoid arthritis (RA).
In a retrospective cross-sectional study, including PsA and matched RA patients, 44 joint counts (TJC, SJC), calprotectin, ESR and CRP were measured. US of wrists and MCPs 1-5 was performed, with grey-scale (GS) and power Doppler (PD) scored 0-3 at each site, summed in a total score. The correlation between calprotectin, clinical and US variables was evaluated by Spearman's coefficient, the predictivity by calprotectin of US by regression. Secondary analyses separating polyarticular PsA and using different US definitions (GS>1, PD>1) were performed.
78 PsA and 78 RA were included (PsA male 32%; mean age 51.7 (13.5)). Calprotectin did not significantly differ in PsA and RA. In PsA, calprotectin correlated with GS score (ρ=0.340, p=0.008), PD score (ρ=0.292, p=0.023) and the presence of PD (ρ=0.263, p=0.042); in RA there were no significant correlations. In polyarticular PsA, a significant correlation between calprotectin and GS (ρ=0.369, p=0.019) and PD scores (ρ=0.363, p=0.021) was confirmed. In both PsA and RA, calprotectin and CRP significantly correlated, while SJC and TJC did not. In the regression analysis, calprotectin did not predict US variables in PsA. Similar results were achieved in RA.
In early PsA, serum calprotectin correlates with US measures of disease activity. Our results provide preliminary evidence for the application of this biomarker in early PsA.
我们旨在评估早发性银屑病关节炎（PsA）和类风湿关节炎（RA）患者血清钙卫蛋白与临床和超声（US）变量之间的相关性。
在一项回顾性横断面研究中，纳入了 PsA 和匹配的 RA 患者，测量了 44 个关节计数（TJC、SJC）、钙卫蛋白、ESR 和 CRP。对腕关节和 MCP1-5 进行了 US 检查，对每个部位的灰阶（GS）和能量多普勒（PD）评分进行 0-3 分的评分，并将总分相加。通过 Spearman 系数评估钙卫蛋白与临床和 US 变量之间的相关性，通过回归评估钙卫蛋白对 US 的预测能力。还进行了分离多关节炎性 PsA 和使用不同 US 定义（GS>1、PD>1）的二次分析。
共纳入 78 例 PsA 和 78 例 RA 患者（PsA 男性 32%；平均年龄 51.7（13.5）岁）。PsA 和 RA 患者的钙卫蛋白无显著差异。在 PsA 中，钙卫蛋白与 GS 评分（ρ=0.340，p=0.008）、PD 评分（ρ=0.292，p=0.023）和 PD 存在（ρ=0.263，p=0.042）相关；在 RA 中，无显著相关性。在多关节炎性 PsA 中，钙卫蛋白与 GS（ρ=0.369，p=0.019）和 PD 评分（ρ=0.363，p=0.021）之间的相关性得到了证实。在 PsA 和 RA 中，钙卫蛋白和 CRP 显著相关，而 SJC 和 TJC 则没有。在回归分析中，钙卫蛋白不能预测 PsA 的 US 变量。RA 也得到了类似的结果。
在早期 PsA 中，血清钙卫蛋白与 US 疾病活动度指标相关。我们的研究结果为这一生物标志物在早期 PsA 中的应用提供了初步证据。
