Ceccamea A, Dominici C, Clerico A, Ferrante E, Vignetti P, Castello M A
Tumori. 1987 Feb 28;73(1):85-9. doi: 10.1177/030089168707300117.
The authors report on a child affected with bilateral renal tumor, which was treated with cancer chemotherapy before and after surgery. Twenty-eight months after the discontinuance of therapy, a neoplasm was disclosed in the left kidney and then removed. Histologically, the bilateral tumor excised by the first surgery could be classified as biphasic Wilms' tumor, rhabdomyomatous variant, whereas the neoplasm removed by the second surgery was the typical triphasic Wilms' tumor. The authors suggest that preoperative chemotherapy might have played a role in the histologic changes of the initial tumor. Nonetheless, it is also tempting to postulate that the two histologic variants of Wilms' tumor could have occurred in the patient in spite of any treatment.
作者报告了一名患有双侧肾肿瘤的儿童，该患儿在手术前后均接受了癌症化疗。治疗停止28个月后，左肾发现了一个肿瘤，随后将其切除。组织学上，第一次手术切除的双侧肿瘤可归类为双相性威尔姆斯瘤，横纹肌瘤样变体，而第二次手术切除的肿瘤是典型的三相性威尔姆斯瘤。作者认为术前化疗可能在初始肿瘤的组织学变化中起了作用。尽管如此，也很容易推测，即使没有任何治疗，该患者也可能出现威尔姆斯瘤的两种组织学变体。
