Department of Orthopedics, Fenghua People's Hospital, Ningbo, Zhejiang, China.
J Rehabil Med. 2018 Nov 7;50(10):860-865. doi: 10.2340/16501977-2366.
To investigate the effect of hyaluronic acid on functional recovery and pain control in patients following knee arthroscopy.
A systematic review and meta-analysis was conducted to explore the efficacy of hyaluronic acid following knee arthroscopy.
Randomized controlled trials (RCTs) assessing the effect of hyaluronic acid in knee arthroscopy were included. A meta-analysis was performed using the random-effect model.
Six RCTs involving 310 patients were included in the meta-analysis. Overall, compared with control intervention following knee arthroscopy, hyaluronic acid treatment was found to significantly increase Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores (mean difference 11.43; 95% confidence intervals (95% CI) 1.39-21.47; p = 0.03), but had no impact on pain scores at 2 weeks (mean difference -0.16; 95% CI -0.81-0.49; p = 0.63), pain scores at 6 weeks (mean difference 0.01; 95% CI -0.86-0.89; p = 0.98), pain scores at 12 weeks (mean difference -0.51; 95% CI -1.56-0.53; p = 0.34). In addition, pain on motion was significantly reduced after knee arthroscopy (risk ratio (RR) 0.22; 95% CI 0.06-0.79; p = 0.02).
Compared with control intervention after knee arthroscopy, hyaluronic acid treatment was found to significantly improve WOMAC score and decrease pain on motion, but had no substantial influence on pain scores at 2, 6 and 12 weeks after knee arthroscopy.
探讨膝关节镜检查后透明质酸对患者功能恢复和疼痛控制的影响。
系统评价和荟萃分析旨在探索膝关节镜检查后透明质酸的疗效。
纳入评估膝关节镜检查中透明质酸作用的随机对照试验（RCT）。使用随机效应模型进行荟萃分析。
荟萃分析纳入了 6 项 RCT，共 310 名患者。总体而言，与膝关节镜检查后的对照干预相比，透明质酸治疗发现可显著增加西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分（平均差值 11.43；95%置信区间（95%CI）1.39-21.47；p=0.03），但对 2 周时的疼痛评分无影响（平均差值-0.16；95%CI-0.81-0.49；p=0.63）、6 周时的疼痛评分（平均差值 0.01；95%CI-0.86-0.89；p=0.98）和 12 周时的疼痛评分（平均差值-0.51；95%CI-1.56-0.53；p=0.34）。此外，膝关节镜检查后运动时的疼痛显著减轻（风险比（RR）0.22；95%CI 0.06-0.79；p=0.02）。
与膝关节镜检查后的对照干预相比，透明质酸治疗发现可显著改善 WOMAC 评分，减轻运动时的疼痛，但对膝关节镜检查后 2、6 和 12 周时的疼痛评分没有实质性影响。
