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[体位性直立性心动过速综合征]

[Postural orthostatic tachycardia syndrome].

作者信息

Åberg Ida, Mattsson Gustav, Magnusson Peter

机构信息

Uppsala universitet - Centrum för forskning och utveckling, Region Gävleborg Gävle, Sweden Uppsala universitet - Centrum för forskning och utveckling, Region Gävleborg Gävle, Sweden.

Uppsala Universitet, Centrum för forskning och utveckling, Region Gävleborg/Gävle - Gävle, Sweden - Gävle, Sweden.

出版信息

Lakartidningen. 2018 Oct 9;115:FAUW.

PMID:30299528
Abstract

Postural orthostatic tachycardia syndrome (POTS) is a condition where the patient experiences tachycardia (a rise in heart rate of at least 30 beats per minute, 40 in people between the ages of 12 and 19) upon assuming the upright position, in the absence of orthostatic hypotension (a fall in systolic blood pressure of more than 20 mmHg). The majority of patients are young women. Symptoms are experienced frequently during standing, and include dizziness, fatigue, palpitations, tremulousness, blurred vision and sometimes syncope - although presyncope is more common. The diagnosis requires that symptoms have been present for at least six months and lack another medical explanation. The pathophysiology is believed to be multifactorial; peripheral sympathetic denervation, excessive sympathetic drive, hypovolemia and deconditioning have been reported in POTS. Patient education is fundamental in the management of POTS, including information regarding symptoms and exacerbating factors as well as methods for increasing arterial pressure. Exercise is believed to be effective. Several drugs can be used to relieve symptoms, although none of them are licensed for the treatment of POTS. We describe a case that illustrates that POTS can be debilitating, which requires awareness of the condition among clinicians.

摘要

体位性直立性心动过速综合征(POTS)是一种患者在没有直立性低血压(收缩压下降超过20 mmHg)的情况下,在处于直立姿势时会出现心动过速(心率至少每分钟增加30次,12至19岁的人增加40次)的病症。大多数患者为年轻女性。症状在站立时经常出现,包括头晕、疲劳、心悸、震颤、视力模糊,有时还会出现晕厥——尽管前驱晕厥更为常见。诊断要求症状至少出现六个月且没有其他医学解释。据信其病理生理是多因素的;POTS患者中已报告有外周交感神经去神经支配、交感神经驱动过度、血容量不足和身体机能失调。患者教育是POTS管理的基础,包括有关症状和加重因素的信息以及增加动脉压的方法。运动被认为是有效的。有几种药物可用于缓解症状,尽管它们均未获许可用于治疗POTS。我们描述了一个病例,该病例表明POTS可能使人衰弱,这需要临床医生了解该病症。

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引用本文的文献

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Heart rate and heart rate variability comparison between postural orthostatic tachycardia syndrome versus healthy participants; a systematic review and meta-analysis.体位性直立性心动过速综合征与健康参与者的心率及心率变异性比较:一项系统评价与荟萃分析
BMC Cardiovasc Disord. 2019 Dec 30;19(1):320. doi: 10.1186/s12872-019-01298-y.