Hozawa J, Fukuoka K, Usami S, Kamimura T, Hozawa K
Auris Nasus Larynx. 1986;13 Suppl 2:S21-7. doi: 10.1016/s0385-8146(86)80052-9.
After introducing potassium ion through the round window into the perilymphatic space of 40 guinea pigs by means of iontophoresis, physiological and histochemical investigations were performed to determine the role of the high perilymphatic potassium concentration in the vertiginous attack of Ménière's disease. About 15 min after the iontophoretic procedure, electronystagmography revealed irritative nystagmus for the first 5 min and then paralytic nystagmus for the following 6 to 24 hr. Histochemical analysis of the vestibular sensory epithelia revealed the increased activity of succinic dehydrogenase and Na-K-ATPase during irritative nystagmus and the decreased activity during paralytic nystagmus. The Na-K-ATPase activity was dominant in the synaptic area between the hair cells and the nerve-endings of the vestibular sensory epithelia. There was some delay between the reversal of nystagmus-direction and the change of enzyme activity. This delay was thought to be produced by the central regulatory mechanism for the disturbed tonus-balance in the vestibular nucleus. On the other hand, electrocochleography revealed the decrease of the action potential without any initial irritative cochlear sign, and the enzyme activity of the cochlear sensory cells was decreased from the beginning.
通过离子电渗疗法经圆窗将钾离子导入40只豚鼠的外淋巴间隙后，进行了生理和组织化学研究，以确定外淋巴中高钾浓度在梅尼埃病眩晕发作中的作用。离子电渗疗法约15分钟后，眼震电图显示最初5分钟出现刺激性眼震，随后6至24小时出现麻痹性眼震。前庭感觉上皮的组织化学分析显示，在刺激性眼震期间琥珀酸脱氢酶和钠钾ATP酶的活性增加，而在麻痹性眼震期间活性降低。钠钾ATP酶活性在前庭感觉上皮毛细胞与神经末梢之间的突触区域占主导地位。眼震方向反转与酶活性变化之间存在一定延迟。这种延迟被认为是由前庭核中紧张性平衡紊乱的中枢调节机制产生的。另一方面，耳蜗电图显示动作电位降低，且无任何初始刺激性耳蜗征象，耳蜗感觉细胞的酶活性从一开始就降低。
