[内科中的个性化医疗]
[PERSONALIZED MEDICINE IN INTERNAL MEDICINE].
作者信息
Kukes V G, Marinin V F, Olefir Yu V, Ramenskaya G V, Lazareva N B, Smirnov V V, Zhuravleva M V, Prokofiev A B, Shih E V, Zhestovskaia A S, Rumyantsev N A, Mandich D V, Goroshko O A
出版信息
Klin Med (Mosk). 2017;95(3):197-200.
Personalized medicine - a new direction in medicine, which is based on the study of various biomarkers and the use of new methods of molecular analysis (primarily evaluating the activity of isoenzymes of cytochrome P450), allowing individualized approach to the selection of both the drugs and the selection of the dosing regimen for the purpose of maximize the effectiveness and safety of pharmacotherapy. This personalized medicine is to change the development and use of preventive and curative interventions. Genetic polymorphism isozymes of cytochrome P450 may determine the individual activity of a particular isozyme, and thus, to predict the clinical effectiveness, and in some cases, the risk of adverse reactions. The article is an example of the use of information on the activity of cytochrome P450 in clinical practice in matters of diagnosis, treatment and prevention of diseases. The scheme of the five best-known activity of isoenzymes of cytochrome P450 is shown.
个性化医疗——医学领域的一个新方向，它基于对各种生物标志物的研究以及新的分子分析方法的应用（主要是评估细胞色素P450同工酶的活性），从而能够以个体化的方式选择药物和确定给药方案，以实现药物治疗的有效性和安全性最大化。这种个性化医疗正在改变预防性和治疗性干预措施的研发与应用。细胞色素P450的基因多态性同工酶可能决定特定同工酶的个体活性，进而预测临床疗效，在某些情况下还能预测不良反应风险。本文是细胞色素P450活性信息在疾病诊断、治疗和预防临床实践中的应用实例。文中展示了细胞色素P450五种最知名同工酶活性的示意图。
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