Pearson G R
AIDS Res. 1986 Dec;2 Suppl 1:S49-56.
The Epstein-Barr Virus (EBV) has been studied extensively as a human cancer virus. Until recently, however, little was known about the viral genes encoding for different proteins involved in the virus immortalization and replication cycles. Most of the efforts have been directed at those genes expressed in immortalized cells. However, more recently, there has also been advances in the mapping of genes encoding for polypeptides expressed in the virus replication cycle and in the characterization of the proteins encoded by these genes. The purpose of this article is to review some of these new developments in identifying viral genes and their products. In addition, the current status of the development of a subviral vaccine against this virus is discussed.
爱泼斯坦-巴尔病毒（EBV）作为一种人类癌症病毒已得到广泛研究。然而，直到最近，对于编码参与病毒永生化和复制周期的不同蛋白质的病毒基因仍知之甚少。大多数研究工作都集中在永生化细胞中表达的那些基因上。然而，最近在绘制病毒复制周期中表达的多肽编码基因图谱以及对这些基因编码的蛋白质进行表征方面也取得了进展。本文的目的是综述在鉴定病毒基因及其产物方面的一些新进展。此外，还讨论了针对该病毒的亚病毒疫苗的开发现状。
