Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Macromol Biosci. 2018 Dec;18(12):e1800240. doi: 10.1002/mabi.201800240. Epub 2018 Oct 10.
Different strategies of chemotherapeutics-based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side effects limit their efficacy and application in the clinic. Local drug co-delivery systems based on injectable hydrogels may have considerable advantages, such as a facile drug-delivery procedure, targeted delivery of antitumor agents to tumor sites in a sustained manner, and markedly reduced systemic toxicities. Thus, in recent years, these systems have received increasing attention and consequently various injectable hydrogels have been tested as platforms for local chemotherapeutics-based combination antitumor therapy. In this review, the focus is on recent advances in injectable hydrogel-based drug co-delivery systems for local combination antitumor therapy, including multiple chemotherapeutics combination therapy, chemo-immunotherapy, chemo-radiotherapy, and hyperthermia-chemotherapy. Moreover, the rationale and preparation of local co-delivery systems are summarized and discussed.
基于化疗的联合癌症治疗的不同策略已经表现出增强的抗肿瘤效率，并广泛用于临床癌症治疗。然而，全身性给药系统的几个缺点，包括肿瘤部位药物积累低和显著的全身副作用，限制了它们在临床上的疗效和应用。基于可注射水凝胶的局部药物共递药系统可能具有相当多的优势，如简便的给药程序、以持续的方式将抗肿瘤药物靶向递送到肿瘤部位，以及显著降低全身毒性。因此，近年来，这些系统受到了越来越多的关注，因此各种可注射水凝胶已被测试为局部基于化疗的联合抗肿瘤治疗的平台。在这篇综述中，重点介绍了基于可注射水凝胶的药物共递药系统在局部联合抗肿瘤治疗方面的最新进展，包括多种化疗联合治疗、化疗免疫治疗、化疗放疗以及热化疗。此外，还总结和讨论了局部共递药系统的原理和制备。
