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由生理学家主导的多巴酚丁胺负荷超声心动图检查的安全性和有效性:来自一家三级心脏中心的经验。

Safety and efficacy of physiologist-led dobutamine stress echocardiography: experience from a tertiary cardiac centre.

作者信息

Ntoskas Theodoros, Ahmad Farhanda, Woodmansey Paul

机构信息

Department of Cardiology, Heart and Lung Centre, New Cross Hospital, Wolverhampton, UK

出版信息

Echo Res Pract. 2018 Sep 1;5(3):105-112. doi: 10.1530/ERP-18-0038.

Abstract

BACKGROUND

Dobutamine stress echocardiography (DSE) services have traditionally been medically led. In some UK institutions, DSE lists are led by physiologists with medical support. In our tertiary cardiac centre at New Cross Hospital (NCH), the DSE service was established by a consultant echocardiographer. Following intensive training and assessment, the Trust approved drug administration by named senior cardiac physiologists. We believe this is the first report of a cardiac physiologist-managed DSE service, including physiologist drug administration. We have assessed the feasibility, safety and validity of this physiologist-led DSE service.

METHODS

Retrospective analysis of 333 patients undergoing stress echocardiogram for inducible reversible ischaemia, myocardial viability and valvular heart disease over 6 months. Patients’ case notes review after 18–24 months.

RESULTS

Overall, 92% of all cases (306) were performed by physiologists. In 300 studies, dobutamine was administered. The majority of the referrals were for coronary artery disease (CAD) assessment (281). In 235 cases, the study was uncomplicated. Sixty-seven patients developed dobutamine-related side effects. In 16 cases, complications led to early termination of the study. In two cases, urgent medical review was needed. Of the 281 studies for CAD assessment, 239 were negative for ischaemia, 28 were positive and 14 inconclusive. In 5 out of 28 cases with echocardiogram, evidence of inducible ischaemia, coronary angiography revealed unobstructed coronary arteries.

CONCLUSION

This study demonstrates the safety and effectiveness of this practice and provides potential for the expansion of the physiologists’ role and physiologist-led DSE services in other hospitals.

摘要

背景

传统上,多巴酚丁胺负荷超声心动图(DSE)检查由医学专业人员主导。在英国的一些机构中,DSE检查清单由生理学家主导,并由医学人员提供支持。在我们位于纽克罗斯医院(NCH)的三级心脏中心,DSE检查服务由一位超声心动图顾问医生建立。经过强化培训和评估后,信托机构批准由指定的资深心脏生理学家进行药物管理。我们认为这是第一份关于由心脏生理学家管理的DSE检查服务的报告,包括生理学家进行药物管理。我们评估了这种由生理学家主导的DSE检查服务的可行性、安全性和有效性。

方法

对333例在6个月内接受负荷超声心动图检查以评估诱发性可逆性缺血、心肌活力和瓣膜性心脏病的患者进行回顾性分析。在18 - 24个月后复查患者病历。

结果

总体而言,所有病例中的92%(306例)由生理学家完成。在300项研究中,使用了多巴酚丁胺。大多数转诊是用于评估冠状动脉疾病(CAD)(281例)。在235例病例中,检查过程无并发症。67例患者出现了与多巴酚丁胺相关的副作用。在16例病例中,并发症导致检查提前终止。在2例病例中,需要紧急医学评估。在281项用于CAD评估的研究中,239项缺血检查结果为阴性,28项为阳性,14项不确定。在28例有超声心动图检查结果显示诱发性缺血的病例中,有5例冠状动脉造影显示冠状动脉无阻塞。

结论

本研究证明了这种做法的安全性和有效性,并为其他医院扩大生理学家的角色和由生理学家主导的DSE检查服务提供了可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f69/6074818/cf0a5687a6cf/erp-5-105-g001.jpg

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