Astley B A, Hughes R, Payne J P
Br J Anaesth. 1987 Feb;59(2):206-10. doi: 10.1093/bja/59.2.206.
Alcuronium 0.2 mg kg-1 was given to six patients to investigate the simultaneous recovery of breathing and peripheral neuromuscular function. Anaesthesia was maintained with 66% nitrous oxide in oxygen supplemented with 0.5% halothane, and the patients were ventilated to normocarbia. Patients were disconnected from the ventilator after the reappearance of the tetanic response. This response returned at a mean time of 19.2 min after the injection of alcuronium and oxygenation was maintained thereafter by means of apnoeic diffusion. Spontaneous breathing returned at a mean time of 23.6 min after the injection of alcuronium. Sixty minutes after the administration of alcuronium, respiratory exchange was judged adequate, and at that time neuromuscular function was still markedly depressed with a tetanic height less than 25% of control. It was concluded that, because of the slow recovery of neuromuscular function, alcuronium should be reserved for the longer surgical procedure.
给6名患者注射阿库氯铵，剂量为0.2毫克/千克，以研究呼吸和外周神经肌肉功能的同时恢复情况。麻醉维持采用66%氧化亚氮与氧气混合，并补充0.5%氟烷，患者通气至正常碳酸血症。出现强直反应后，患者与呼吸机断开连接。该反应在注射阿库氯铵后平均19.2分钟恢复，此后通过无呼吸扩散维持氧合。自主呼吸在注射阿库氯铵后平均23.6分钟恢复。注射阿库氯铵60分钟后，判断呼吸交换充分，但此时神经肌肉功能仍明显受抑制，强直高度低于对照的25%。得出的结论是，由于神经肌肉功能恢复缓慢，阿库氯铵应留用于较长的外科手术。
