Fourie P J, Lambert P A, Versace M, Bodemer W P, van der Merwe C A, Lessing A J
S Afr Med J. 1986 Apr 26;69(9):553-5.
Atracurium 0.3 mg/kg was compared with alcuronium 0.25 mg/kg as the sole muscle relaxant for tracheal intubation and abdominal relaxation for gynaecological laparoscopy in 46 patients during nitrous oxide, oxygen and halothane anaesthesia. Speed of onset, intubation conditions, effect on blood pressure and pulse rate, and ease of reversal were compared. Alcuronium had a significantly faster onset of action than atracurium; intubation conditions were adequate and abdominal relaxation was satisfactory for both drugs. The effect of atracurium was readily reversible within 10 minutes; in contrast alcuronium was significantly more resistant and mean recovery time was 28.03 minutes. Although alcuronium provided good muscle relaxation, it is not suitable for short procedures because of difficulty in reversing its action. Atracurium allowed earlier and more complete reversal of neuromuscular block.
在46例接受氧化亚氮、氧气和氟烷麻醉的患者中，比较了阿曲库铵0.3mg/kg与阿库氯铵0.25mg/kg作为气管插管和妇科腹腔镜检查腹部松弛的唯一肌肉松弛剂的效果。比较了起效速度、插管条件、对血压和脉搏率的影响以及逆转的难易程度。阿库氯铵的起效速度明显快于阿曲库铵；两种药物的插管条件均充分，腹部松弛效果令人满意。阿曲库铵的作用在10分钟内即可迅速逆转；相比之下，阿库氯铵的逆转明显更困难，平均恢复时间为28.03分钟。尽管阿库氯铵提供了良好的肌肉松弛效果，但由于其作用难以逆转，不适合用于短时间手术。阿曲库铵能使神经肌肉阻滞更早、更完全地逆转。
