视上核大细胞神经元对前脑α-肾上腺素能受体刺激的反应。

Response of supraoptic magnocellular neurons to stimulation of forebrain alpha-adrenoceptors.

作者信息

Mitchell L D, Callahan M F, Wilkin L D, Johnson A K

出版信息

Brain Res. 1986 Dec 10;399(2):346-51. doi: 10.1016/0006-8993(86)91526-x.

Abstract

Effects of alpha-adrenoceptor agents on electrophysiologically and immunohistochemically identified supraoptic nucleus (SON) vasopressin (VP) units were investigated by intracarotid infusion. Clonidine, an alpha 2-adrenoceptor agonist always excited SON units and alpha 2-adrenoceptor antagonists consistently inhibited them. alpha 1-Adrenoceptor agents produced inconsistent responses. The results implicate forebrain alpha 2-adrenergic receptors in the excitation of SON VP neurons.

摘要

通过颈内动脉灌注，研究了α-肾上腺素能受体激动剂对经电生理学和免疫组织化学鉴定的视上核（SON）血管加压素（VP）神经元的作用。α2-肾上腺素能受体激动剂可乐定总是能兴奋SON神经元，而α2-肾上腺素能受体拮抗剂则始终抑制它们。α1-肾上腺素能受体激动剂产生的反应不一致。这些结果表明，前脑α2-肾上腺素能受体参与了SON VP神经元的兴奋过程。