Hilal E Y, Wanebo H J, Pinsky C M, Middleman P, Strong E W, Oettgen H F
Am J Surg. 1977 Oct;134(4):468-73. doi: 10.1016/0002-9610(77)90380-4.
Patients with mucosal squamous cell carcinoma of the head and neck generally have suppressed T cell function, and this suppression tends to be more pronounced with progression of disease. The prognostic relationships of multiple tests of immune function were analyzed in 183 clinically staged patients. Correlation of immune parameters with prognosis was evident only with the DNCB response, which correlated with recurrence in stages I and II disease (but not in stages III and IV). There was no correlation of any of the in vitro tests of immunofunction with recurrence in any stage. There were no correlations between any of the immune parameters and age or sex nor between DNCB reactivity and any of the in vitro responses.
头颈部黏膜鳞状细胞癌患者通常存在T细胞功能抑制，且这种抑制往往随着疾病进展而更加明显。对183例临床分期患者的多项免疫功能测试的预后关系进行了分析。免疫参数与预后的相关性仅在二硝基氯苯（DNCB）反应中明显，其与Ⅰ期和Ⅱ期疾病的复发相关（但Ⅲ期和Ⅳ期不相关）。任何免疫功能体外测试与任何阶段的复发均无相关性。任何免疫参数与年龄或性别之间均无相关性，DNCB反应性与任何体外反应之间也无相关性。
