线性钆基造影剂（钆喷酸葡胺和钆双胺）在儿科患者平扫 T1 加权图像上的高信号强度。

Linear gadolinium-based contrast agent (gadodiamide and gadopentetate dimeglumine)-induced high signal intensity on unenhanced T -weighted images in pediatric patients.

机构信息

Department of Radiology, University of Yamanashi, Yamanashi, Japan.

出版信息

J Magn Reson Imaging. 2019 Apr;49(4):1046-1052. doi: 10.1002/jmri.26311. Epub 2018 Oct 11.

DOI:10.1002/jmri.26311

PMID:30307671

Abstract

BACKGROUND

Recent studies of adults have found an association between hyperintensity of the dentate nucleus (DN) and globus pallidus (GP) on T -weighted images (T WI) and a history of linear gadolinium-based contrast agent (GBCA) administration. Several reports have also focused on this phenomenon in pediatric patients; however, data in the current literature remains limited.

PURPOSE/HYPOTHESIS: To evaluate the associations between DN and GP T -signal increase and previous administration of linear GBCAs in pediatric patients.

STUDY TYPE

Single-center, retrospective, cross-sectional study.

POPULATION

We included pediatric patients with histories of ≥5 linear GBCA (gadodiamide and gadopentetate dimeglumine) administrations (the "≥5 Linear GBCA administrations" group), 1-4 administrations (the "1-4 Linear GBCA administrations" group), and no history of GBCA administration (the "No GBCA administration" group). Each group included 42 patients. Therefore, 126 patients (male:female, 72:54; median age, 16 [range, 4-18] years) were included in this study.

FIELD STRENGTH/SEQUENCE: 1.5T/ Spin-echo unenhanced T -weighted imaging.

ASSESSMENT

Unenhanced T -weighted images were quantitatively analyzed by two radiologists. The DN-to-pons and GP-to-thalamus signal intensity ratios (DN-to-pons and GP-to-thalamus ratios, respectively) were compared.

STATISTICAL TESTS

Wilcoxon test with the Bonferroni correction and intraclass correlation coefficients.

RESULTS

The DN-to-pons ratio increased as the number of GBCA administrations increased (P < 0.0063). The GP-to-thalamus ratio of the "≥5 Linear GBCA administrations" group was significantly higher than those of the other two groups (P < 0.0001). The GP-to-thalamus ratio of the "1-4 Linear GBCA administrations" group did not differ significantly from that of the "No GBCA administration" group (P = 1.000). The DN-to-pons and GP-to-thalamus ratios' interobserver intraclass correlation coefficients were excellent (0.8236) and good (0.6738), respectively.

DATA CONCLUSION

High signal intensities in the DN and GP on T WI were associated with previous linear GBCA administration in pediatric patients.

LEVEL OF EVIDENCE

3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1046-1052.

摘要

背景

最近对成年人的研究发现，T 加权图像（TWI）上齿状核（DN）和苍白球（GP）的高信号与线性钆基造影剂（GBCA）的使用史有关。一些报告也集中在儿科患者的这种现象上;然而，目前文献中的数据仍然有限。

目的/假设：评估 DN 和 GP T 信号增加与儿科患者先前线性 GBCA 给药之间的相关性。

研究类型

单中心、回顾性、横断面研究。

人群

我们纳入了有≥5 次线性 GBCA（钆喷替酸葡甲胺和钆喷替酸二葡甲胺）给药史（“≥5 次线性 GBCA 给药”组）、1-4 次给药史（“1-4 次线性 GBCA 给药”组）和无 GBCA 给药史（“无 GBCA 给药”组）的儿科患者。每个组包括 42 名患者。因此，本研究共纳入 126 名患者（男：女，72：54；中位年龄 16 岁[范围，4-18 岁]）。

场强/序列：1.5T/自旋回波未增强 TWI。

评估

两名放射科医生对未增强 TWI 进行定量分析。比较齿状核-桥脑信号强度比（DN-to-pons 比）和苍白球-丘脑信号强度比（GP-to-thalamus 比）。

统计检验

Wilcoxon 检验，Bonferroni 校正和组内相关系数。

结果

随着 GBCA 给药次数的增加，DN-to-pons 比值增加（P<0.0063）。“≥5 次线性 GBCA 给药”组的 GP-to-thalamus 比值明显高于其他两组（P<0.0001）。“1-4 次线性 GBCA 给药”组的 GP-to-thalamus 比值与“无 GBCA 给药”组无显著差异（P=1.000）。DN-to-pons 和 GP-to-thalamus 比值的观察者间组内相关系数分别为优秀（0.8236）和良好（0.6738）。