Freie Universität Berlin, Institute for Biology/Genetics, Takustrasse 6, 14195 Berlin, Germany.
Freie Universität Berlin, Institute for Biology/Genetics, Takustrasse 6, 14195 Berlin, Germany; NeuroCure, Charite, Chariteplatz 1, 10117 Berlin, Germany.
Neuron. 2018 Oct 10;100(1):6-8. doi: 10.1016/j.neuron.2018.09.035.
Neurexins have been established as a major coordinator of synapse assembly, functioning through interactions with postsynaptic cell adhesion molecules. Kurshan et al. (2018) now show that a C. elegans "dwarf neurexin" lacking its extracellular interaction domains can conduct synapse formation independent of postsynaptic partners.
神经连接蛋白已被确定为突触组装的主要协调者，通过与突触后细胞粘附分子的相互作用发挥作用。Kurshan 等人（2018 年）现在表明，一种缺乏细胞外相互作用域的“矮小神经连接蛋白”可以独立于突触后伴侣进行突触形成。
