Department of Neurology, Juntendo University School of Medicine, 3-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan.
Department of Radiology, Juntendo University School of Medicine, 3-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan.
J Neurol Sci. 2018 Dec 15;395:88-90. doi: 10.1016/j.jns.2018.09.027. Epub 2018 Sep 24.
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease; it is characterized as a transmissible spongiform encephalopathy. Previously, only two case reports have discussed crossed cerebellar diaschisis (CCD) and sCJD. Herein, we detected CCD in five patients with sCJD and four patients with genetic CJD through SPECT. The combined data of the nine patients further supported CCD when analyzed by 3D-SSP. CCD can occur in several disorders, including, stroke, epilepsy, and encephalitis. Hence, CCD possibly could help in making earlier CJD diagnoses. Further studies with more patients are necessary to confirm the strong relationship here suggested between CJD and CCD.
散发性 Creutzfeldt-Jakob 病（sCJD）是人类朊病毒病中最常见的形式；它被定义为一种传染性海绵状脑病。先前，仅有两份病例报告讨论了交叉性小脑失联络（CCD）和 sCJD。在此，我们通过 SPECT 检测到 5 例 sCJD 和 4 例遗传性朊病毒病患者的 CCD。当通过 3D-SSP 对 9 例患者的综合数据进行分析时，进一步支持了 CCD 的存在。CCD 可能发生于多种疾病中，包括中风、癫痫和脑炎。因此，CCD 可能有助于更早地诊断 CJD。有必要开展更多患者的进一步研究，以确认此处建议的 CJD 和 CCD 之间的强相关性。
