Harris-Love Michael O, Avila Nilo A, Adams Bernadette, Zhou June, Seamon Bryant, Ismail Catheeja, Zaidi Syed H, Kassner Courtney A, Liu Frank, Blackman Marc R
Muscle Morphology, Mechanics, and Performance Laboratory, Geriatrics Service, Veterans Affairs Medical Center, Washington, DC 20422, USA.
Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
J Clin Med. 2018 Oct 10;7(10):340. doi: 10.3390/jcm7100340.
Estimates of muscle tissue composition may have greater prognostic value than lean body mass levels regarding health-related outcomes. Ultrasound provides a relatively low cost, safe, and accessible mode of imaging to assess muscle morphology. The purpose of this study was to determine the construct validity of muscle echogenicity as a surrogate measure of muscle quality in a sample of older, predominantly African American (AA) participants. We examined the association of rectus femoris echogenicity with mid-thigh computed tomography (CT) scan estimates of intra- and intermuscular adipose tissue (IMAT), basic metabolic parameters via blood sample analysis, muscle strength, and mobility status. This observational study was conducted at a federal medical center and included 30 community-dwelling men (age, 62.5 ± 9.2; AA, = 24; Caucasian, = 6). IMAT estimates were significantly associated with echogenicity ( = 0.73, < 0.001). Echogenicity and IMAT exhibited similar associations with the two-hour postprandial glucose values and high-density lipoproteins values ( < 0.04), as well as grip and isokinetic (180°/s) knee extension strength adjusted for body size ( < 0.03). The significant relationship between ultrasound and CT muscle composition estimates, and their comparative association with key health-related outcomes, suggests that echogenicity should be further considered as a surrogate measure of muscle quality.
就健康相关结局而言，肌肉组织成分的估计可能比瘦体重水平具有更大的预后价值。超声提供了一种相对低成本、安全且易于获得的成像方式来评估肌肉形态。本研究的目的是确定在以非洲裔美国人（AA）为主的老年参与者样本中，肌肉回声性作为肌肉质量替代指标的结构效度。我们检查了股直肌回声性与大腿中部计算机断层扫描（CT）对肌内和肌间脂肪组织（IMAT）的估计值、通过血样分析得到的基本代谢参数、肌肉力量和活动状态之间的关联。这项观察性研究在一家联邦医疗中心进行，纳入了30名社区居住男性（年龄，62.5±9.2；AA，n = 24；白种人，n = 6）。IMAT估计值与回声性显著相关（r = 0.73，P < 0.001）。回声性和IMAT与餐后两小时血糖值和高密度脂蛋白值呈现相似的关联（P < 0.04），以及与根据体型调整后的握力和等速（180°/秒）膝关节伸展力量呈现相似的关联（P < 0.03）。超声与CT肌肉成分估计值之间的显著关系，以及它们与关键健康相关结局的比较关联，表明回声性应进一步被视为肌肉质量的替代指标。
