Moore P W, Shying M E, Sodeau J M, Evans J V, Maddalena D J, Farrington K H
Int J Rad Appl Instrum A. 1987;38(1):25-9. doi: 10.1016/0883-2889(87)90231-0.
The characteristics of zirconium molybdate gels were described in Part I of this paper. Here it is shown that zirconium molybdate gel, prepared from neutron irradiated molybdenum oxide with 99Mo specific activities between 4.3 and 13.5 GBq g-1 is sufficiently stable for use as a matrix in preparation of high activity 99mTc generators. Elution efficiencies of generators containing from 2 to 6 g of gel ranged from 83 to 50% for 10 mL elutions. Generators containing 150 g of gel were eluted with efficiencies of 80-98%, with the activity peak in the first 50 mL. Radionuclidic impurities were considerably below the limits set by the British Pharmacopoeia. Although the pH of eluates was less than 4, subsequent treatment with a small zirconium oxide bed provided adjustment to within BP limits, and reduced 99Mo impurity levels tenfold to values near 10(-4)%. No significant differences were found between the biodistributions in rats of radiopharmaceuticals prepared with pertechnetate from gel generators and those from other generators.
钼酸锆凝胶的特性在本文第一部分已有描述。此处表明，由比活度在4.3至13.5GBq g-1之间的经中子辐照的氧化钼制备的钼酸锆凝胶足够稳定，可用作制备高活度99mTc发生器的基质。对于含2至6g凝胶的发生器，10mL洗脱液的洗脱效率在83%至50%之间。含150g凝胶的发生器洗脱效率为80 - 98%，活性峰出现在前50mL。放射性核素杂质大大低于英国药典规定的限值。尽管洗脱液的pH值小于4，但随后用小的氧化锆床进行处理可将其调节至英国药典规定的限值范围内，并将99Mo杂质水平降低至十分之一，达到接近10(-4)%的值。用凝胶发生器的高锝酸盐制备的放射性药物与用其他发生器制备的放射性药物在大鼠体内的生物分布之间未发现显著差异。
