[75硒]L-硒代蛋氨酸的快速化学合成
Fast chemical synthesis of [75Se]L-selenomethionine.
作者信息
Plenevaux A, Cantineau R, Guillaume M, Christiaens L, Tihange G
出版信息
Int J Rad Appl Instrum A. 1987;38(1):59-61. doi: 10.1016/0883-2889(87)90237-1.
A fast chemical synthesis of high specific activity [75Se]L-selenomethionine (10 Ci/mmol--370 GBq/mmol) is described with a view to 73Se labeling and PET studies. The overall radiochemical yield of the preparation is better than 80%. The purification method uses commercially available reverse phase HPLC columns and 9% NaCl as mobile phase. The final labeled compound is obtained in less than 3 h and the chemical, radiochemical and optical purities of the L-isomer are higher than 99.0%.
描述了一种高比活度[75Se]L-硒代蛋氨酸（10 Ci/mmol--370 GBq/mmol）的快速化学合成方法，用于73Se标记和正电子发射断层扫描（PET）研究。该制剂的总放射化学产率优于80%。纯化方法使用市售的反相高效液相色谱柱，以9%氯化钠作为流动相。最终标记化合物在不到3小时内获得，L-异构体的化学、放射化学和光学纯度均高于99.0%。
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