炎症性肠病患者罹患帕金森病的风险：系统评价和荟萃分析。
The risk of Parkinson's disease in inflammatory bowel disease: A systematic review and meta-analysis.
机构信息
Department of General Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, China.
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
出版信息
Dig Liver Dis. 2019 Jan;51(1):38-42. doi: 10.1016/j.dld.2018.09.017. Epub 2018 Sep 21.
BACKGROUND
Several studies have reported an increased prevalence of Parkinson disease (PD) amongst patients with inflammatory bowel disease (IBD) with conflicting results. We aimed to evaluate the risk of PD in the IBD population by conducting a meta-analysis (MA).
METHODS
A systematic review with MA of the existing literature was conducted. The main outcome of interest was the incidence of developing PD in patients previously diagnosed with IBD.
RESULTS
Four studies were included in this MA. The overall risk of PD in IBD was significantly higher than controls (RR 1.41, 95% c.i. 1.19-1.66). Crohn's disease had a 28% increased risk of PD and ulcerative colitis had a 30% increased risk of PD compared to controls (CD: RR 1.28, 95% c.i. 1.08-1.52, UC: RR 1.30, 95% c.i. 1.15-1.47).
CONCLUSION
The MA detected an increased risk of PD in the IBD population and CD/UC subgroup. These results merit further clinical validation in future studies.
背景
几项研究报告称，炎症性肠病（IBD）患者中帕金森病（PD）的患病率增加，但结果存在差异。我们旨在通过荟萃分析（MA）评估 IBD 人群中 PD 的发病风险。
方法
对现有文献进行系统评价和 MA。主要观察结果是先前诊断为 IBD 的患者发生 PD 的发生率。
结果
本 MA 纳入了 4 项研究。IBD 患者发生 PD 的总体风险明显高于对照组（RR 1.41，95%置信区间 1.19-1.66）。与对照组相比，克罗恩病（CD）发生 PD 的风险增加了 28%，溃疡性结肠炎（UC）发生 PD 的风险增加了 30%（CD：RR 1.28，95%置信区间 1.08-1.52，UC：RR 1.30，95%置信区间 1.15-1.47）。
结论
MA 检测到 IBD 人群和 CD/UC 亚组中 PD 的发病风险增加。这些结果值得在未来的研究中进一步进行临床验证。
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