募集和黏附——MRTF 蛋白在细胞迁移中的作用。
SRF'ing and SAP'ing - the role of MRTF proteins in cell migration.
机构信息
Department of Bioengineering, University of Pittsburgh, PA 15213, USA.
Department of Bioengineering, University of Pittsburgh, PA 15213, USA
出版信息
J Cell Sci. 2018 Oct 11;131(19):jcs218222. doi: 10.1242/jcs.218222.
Actin-based cell migration is a fundamental cellular activity that plays a crucial role in a wide range of physiological and pathological processes. An essential feature of the remodeling of actin cytoskeleton during cell motility is the synthesis of factors involved in the regulation of the actin cytoskeleton and cell adhesion in response to growth-factor signaling, and this aspect of cell migration is critically regulated by serum-response factor (SRF)-mediated gene transcription. Myocardin-related transcription factors (MRTFs) are key coactivators of SRF that link actin dynamics to SRF-mediated gene transcription. In this Review, we provide a comprehensive overview of the role of MRTF in both normal and cancer cell migration by discussing its canonical SRF-dependent as well as its recently emerged SRF-independent functions, exerted through its SAP domain, in the context of cell migration. We conclude by highlighting outstanding questions for future research in this field.
基于肌动蛋白的细胞迁移是一种基本的细胞活动，在广泛的生理和病理过程中起着至关重要的作用。在细胞运动过程中肌动蛋白细胞骨架重构的一个重要特征是，根据生长因子信号合成参与肌动蛋白细胞骨架和细胞黏附调节的因子，细胞迁移的这一方面受到血清反应因子 (SRF)-介导的基因转录的严格调控。肌球蛋白相关转录因子 (MRTF) 是 SRF 的关键共激活因子，它将肌动蛋白动力学与 SRF 介导的基因转录联系起来。在这篇综述中，我们通过讨论其典型的 SRF 依赖性以及其最近出现的与 SAP 结构域相关的非依赖性 SRF 功能，全面概述了 MRTF 在正常和癌细胞迁移中的作用，这些功能是在细胞迁移的背景下发挥的。最后，我们强调了该领域未来研究的悬而未决的问题。
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