Brombacher P J, Cremers H M, Verheesen P E, Quanjel-Schreurs R A
Arzneimittelforschung. 1977;27(8):1597-9.
A rapid method for the estimation of sodium-(o-[(2,6-dichlorophenyl)-amino]-phenyl)-acetate (diclofenac-Na, Voltaren) used in the treatment of rheumatic diseases, in human blood plasma is described. The substance is extracted from acidified plasma with dichloromethane and acetylated after evaporation of the organic solvent, whereupon quantitation is performed by gas-liquid chromatography on a 10% OV-17 column, F.I. detection.
本文描述了一种用于估算在治疗风湿性疾病中使用的钠 -（邻 - [（2,6 - 二氯苯基） - 氨基] - 苯基） - 乙酸酯（双氯芬酸钠，扶他林）在人血浆中的快速方法。该物质从酸化血浆中用二氯甲烷萃取，在有机溶剂蒸发后进行乙酰化，然后通过在10% OV - 17柱上的气液色谱法进行定量，采用火焰离子化检测。
