Stanberry L R, Bernstein D I, Burke R L, Pachl C, Myers M G
J Infect Dis. 1987 May;155(5):914-20. doi: 10.1093/infdis/155.5.914.
The natural history of initial and subsequent recurrent herpes simplex virus (HSV) genital infection was studied in guinea pigs immunized with HSV glycoprotein vaccines before vaginal challenge with HSV-2. The vaccines used included HSV-1 glycoprotein B and HSV-1 glycoprotein D, both prepared by recombinant DNA techniques, and mixtures of HSV-1 or HSV-2 glycoproteins, prepared from infected cell monolayers by lectin chromatography. Immunizing guinea pigs with subunit HSV glycoprotein vaccines favorably altered the clinical and virological course of initial infection and substantially reduced the incidence, frequency, and duration of recurrent herpetic infections. The extent of protection was influenced by the nature of the glycoprotein vaccine, the immunizing dose, and the co-administration of adjuvant.
在用单纯疱疹病毒2型（HSV-2）进行阴道攻击之前，对用HSV糖蛋白疫苗免疫的豚鼠的初次及后续复发性单纯疱疹病毒（HSV）生殖器感染的自然史进行了研究。所使用的疫苗包括通过重组DNA技术制备的HSV-1糖蛋白B和HSV-1糖蛋白D，以及通过凝集素色谱法从感染的细胞单层制备的HSV-1或HSV-2糖蛋白混合物。用亚单位HSV糖蛋白疫苗免疫豚鼠可有利地改变初次感染的临床和病毒学进程，并大幅降低复发性疱疹感染的发生率、频率和持续时间。保护程度受糖蛋白疫苗的性质、免疫剂量和佐剂的共同给药影响。
