Department of Ophthalmology, Bağcılar Training and Research Hospital, Istanbul, Turkey.
Department of Internal Medicine, Bağcılar Training and Research Hospital, Istanbul, Turkey.
Adv Clin Exp Med. 2019 Jan;28(1):109-112. doi: 10.17219/acem/85039.
Hashimoto's thyroiditis (HT) is an autoimmune endocrine disorder that results from a dysregulation of the immune system leading to an immune attack on the thyroid gland. It has potential effects on different organs and tissues.
The aim of the study was to investigate the effect of HT on corneal biomechanical properties using the ocular response analyzer (ORA).
A total of 48 patients with HT and 49 healthy subjects were enrolled in the study. The mean age of the patients and healthy subjects was 42.33 ±11.96 and 40.20 ±12.60 years, respectively (p = 0.39). All of the subjects underwent a full ophthalmological examination, including visual acuity, corneal pachymetry with topography, biomicroscopy, and funduscopy. Corneal biomechanical properties, including corneal hysteresis (CH) and corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated IOP (IOPcc) were measured with the ORA.
Central corneal thickness (CCT) in the patient group and the control group were not significantly different (p = 0.65). Corneal hysteresis of the HT patients was significantly lower than that of the control group (p = 0.005). There were no statistically significant differences in CRF between the 2 groups (p = 0.53). Goldmann-correlated IOP and IOPcc were higher in the HT patients, but only IOPcc showed a statistically significant difference (p = 0.001).
In conclusion, our data shows that HT affects corneal biomechanical properties by decreasing CH. Thus, IOPcc measured with the ORA should be taken into account when determining accurate IOP values in patients with HT.
桥本甲状腺炎（HT）是一种自身免疫性内分泌疾病，由免疫系统失调引起，导致甲状腺自身免疫攻击。它可能对不同的器官和组织产生影响。
本研究旨在使用眼反应分析仪（ORA）研究 HT 对角膜生物力学特性的影响。
共纳入 48 例 HT 患者和 49 例健康对照者。患者和健康对照组的平均年龄分别为 42.33±11.96 岁和 40.20±12.60 岁（p=0.39）。所有受试者均行全面眼科检查，包括视力、角膜地形图、生物显微镜和眼底检查。使用 ORA 测量角膜生物力学特性，包括角膜滞后（CH）和角膜阻力因子（CRF）、Goldmann 相关眼压（IOPg）和角膜补偿眼压（IOPcc）。
患者组和对照组的中央角膜厚度（CCT）无显著差异（p=0.65）。HT 患者的角膜滞后明显低于对照组（p=0.005）。两组间 CRF 无统计学差异（p=0.53）。HT 患者的 Goldmann 相关眼压和 IOPcc 较高，但仅 IOPcc 差异有统计学意义（p=0.001）。
总之，我们的数据表明，HT 通过降低 CH 影响角膜生物力学特性。因此，在确定 HT 患者的准确眼压值时，应考虑使用 ORA 测量的 IOPcc。
