Boesken W H, Schindera F, Billingham M, Hardwicke J, White R H, Williams A
Clin Nephrol. 1977 Sep;8(3):395-9.
Dimer and polymer albumin was detected in the urine of a proportion of pantients with a nephrotic syndrome. Most of it was present as S-S bonded dimer and polymer; co-polymers, however, with IgG and alpha (1) anti-trypsin could be demonstrated. It is suggested that albumin polymerizes after it has passed the glomerular membrane. Albumin dimer was associated mainly with minimal change disease and early membranous glomerulopathy in patients, who in general responded well to therapy.
在一部分肾病综合征患者的尿液中检测到了二聚体和多聚体白蛋白。其中大部分以S-S键连接的二聚体和多聚体形式存在；然而，也可以证明存在与IgG和α(1)抗胰蛋白酶的共聚物。有人认为白蛋白在通过肾小球膜后会发生聚合。白蛋白二聚体主要与微小病变性肾病和早期膜性肾小球病相关，这些患者总体上对治疗反应良好。
