Lentini M, Grosso M, Carrozza G, Risitano G
Pathol Res Pract. 1986 Dec;181(6):713-7. doi: 10.1016/S0344-0338(86)80046-2.
183 cases of soft tissue tumors were studied utilizing the immunoperoxidase technique to demonstrate alpha-1-antitrypsin, ferritin and lysozyme. The series comprises 50 malignant lesions, 34 intermediate malignancy lesions, 99 benign lesions of fibrohistiocytic origin, and 23 malignant tumors of non fibrohistiocytic origin. The actual results of the study are as follows: alpha-1-antitrypsin, ferritin and lysozyme were always absent in 10 fibrosarcomas, 2 liposarcomas, 2 Ewing sarcomas, 3 synovial sarcomas, 4 neurofibrosarcomas, and 2 rhabdomyosarcomas, but in 24 malignant fibrous histiocytomas, 34 cases of dermatofibrosarcoma protuberans and 102 benign fibrohistiocytic lesions, these activities were present in a percentage that ranged between 12% and 38% (average 25%). Differences in the frequency of positive reactions did not occur between benign and malignant fibrohistiocytic lesions. The immunohistological examinations carried out have, therefore, only a very limited value for the practical diagnostic evaluation, but, when positive, are important to clarify the histogenesis of the tumor.
利用免疫过氧化物酶技术检测α-1-抗胰蛋白酶、铁蛋白和溶菌酶，对183例软组织肿瘤进行了研究。该系列包括50例恶性病变、34例中间恶性病变、99例纤维组织细胞起源的良性病变以及23例非纤维组织细胞起源的恶性肿瘤。研究的实际结果如下：10例纤维肉瘤、2例脂肪肉瘤、2例尤因肉瘤、3例滑膜肉瘤、4例神经纤维肉瘤和2例横纹肌肉瘤中α-1-抗胰蛋白酶、铁蛋白和溶菌酶均呈阴性，但在24例恶性纤维组织细胞瘤、34例隆突性皮肤纤维肉瘤和102例良性纤维组织细胞病变中，这些活性的阳性率在12%至38%之间（平均25%）。良性和恶性纤维组织细胞病变之间阳性反应频率无差异。因此，所进行的免疫组织学检查对实际诊断评估的价值非常有限，但阳性时对阐明肿瘤的组织发生很重要。
