Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina.
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina.
Brain Behav. 2018 Nov;8(11):e01107. doi: 10.1002/brb3.1107. Epub 2018 Oct 13.
Several studies have supported the use of enriched environments to prevent the manifestation of ASD-like phenotypes in laboratory rodents. While the translational value of such experiments is unknown, the findings have been relatively consistent across many different models.
In the current study, we tested the effects of early environmental enrichment on a mouse model of ASD with high construct validity, the Shank3 ∆e4-22 mice our laboratory previously generated and characterized.
Contrary to previous reports, we found no benefits of enriched rearing, including no change in repetitive self-grooming or hole-board exploration. Instead, we found that early environmental enrichment increased anxiety-like behavior in all mice regardless of genotype and decreased motor performance specifically in wild-type mice.
Although using a different enrichment protocol may have rescued the phenotypes in our mouse model, these results suggest that a "one-size fits all" approach may not be the best when it comes to behavioral intervention for ASD and underscores the need for effective pharmaceutical development in certain genetic syndromes with severe symptom presentation.
多项研究支持使用丰富环境来预防实验室啮齿动物出现 ASD 样表型。虽然此类实验的转化价值尚不清楚，但许多不同模型的研究结果都相对一致。
在当前的研究中，我们测试了早期环境富集对我们实验室之前生成和表征的具有高结构效度的 ASD 小鼠模型的影响，该模型为 Shank3 ∆e4-22 小鼠。
与之前的报告相反，我们没有发现丰富饲养的任何益处，包括重复自我梳理或洞板探索没有变化。相反，我们发现，早期环境富集增加了所有小鼠的焦虑样行为，而不论基因型如何，并且特异性地降低了野生型小鼠的运动表现。
尽管使用不同的富集方案可能挽救了我们的小鼠模型中的表型，但这些结果表明，对于 ASD 的行为干预，“一刀切”的方法可能并不合适，并且强调了在具有严重症状表现的某些遗传综合征中进行有效药物开发的必要性。
