Zheng Y J, Pan M X, Wang Y
Institute of Hepatology, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University; Biomedical Research Center, Southern Medical University, Guangzhou 510515, China; Departments of Hepatobiliary Surgery and Pathology, Zhujiang Hospital, Southern Medical University; Regenerative Medicine Institute of Southern Medical University, Guangzhou 510260, China.
Departments of Hepatobiliary Surgery and Pathology, Zhujiang Hospital, Southern Medical University; Regenerative Medicine Institute of Southern Medical University, Guangzhou 510260, China.
Zhonghua Gan Zang Bing Za Zhi. 2018 Aug 20;26(8):637-640. doi: 10.3760/cma.j.issn.1007-3418.2018.08.017.
Ductular reaction is a kind of repair response to biliary and hepatocellular injury, and the pathological changes include lobular bile duct hyperplasia, matrix change and inflammatory cell infiltrations. In human liver, a ductular reaction originates from the activation and proliferation of hepatic progenitor cells. The activated hepatic progenitor cells, the intermediate hepatocytes and the reactive small bile duct cells together form the cell complex of ductular reaction, which has the dual characteristics of hepatobiliary system and co-expresses the hepatocyte and cholangiocyte antigen. Ductular reaction appears in all kinds of acute and chronic hepatobiliary injury, and plays an important role in liver regeneration and repair, fibrogenesis, cirrhosis formation, and hepatobiliary cancer occurrence and development. Understanding the pathological features and pathophysiological mechanisms of ductular reaction in various clinical hepatobiliary diseases and their role in liver regeneration can provide important suggestion for further exploring new-targeted treatment approach.
小胆管反应是一种对胆管和肝细胞损伤的修复反应，其病理变化包括小叶胆管增生、基质改变和炎症细胞浸润。在人类肝脏中，小胆管反应起源于肝祖细胞的激活和增殖。激活的肝祖细胞、中间型肝细胞和反应性小胆管细胞共同构成小胆管反应的细胞复合体，其具有肝胆系统的双重特征，并共同表达肝细胞和胆管细胞抗原。小胆管反应出现在各种急慢性肝胆损伤中，在肝脏再生与修复、纤维化形成、肝硬化形成以及肝胆肿瘤的发生发展中发挥重要作用。了解各种临床肝胆疾病中小胆管反应的病理特征和病理生理机制及其在肝脏再生中的作用，可为进一步探索新的靶向治疗方法提供重要线索。
