van Leeuwen E H, Postma A, Oosterhuis J W, Meiring A, Cornelisse C J, Koudstaal J, Molenaar W M
Virchows Arch A Pathol Anat Histopathol. 1987;410(6):487-94. doi: 10.1007/BF00781683.
In children with Wilms' tumours the length of survival is greatly influenced by success in preventing or controlling metastatic disease. The current study focuses on the morphological aspects of metastases when compared with the primary tumour. In 8 patients it appeared that blastema is the most likely component to metastasize, whereas epithelial and stromal components were hardly, if at all, represented in metastases. Furthermore, flow cytometric DNA ploidy determinations on 4 cases showed that both the primary tumours and the metastases had stemlines in the diploid and low aneuploid (hyperdiploid) range. Finally, in four cases the influence of therapy on morphology of the primary tumours was analyzed. In these cases blastema seemed to be the component most sensitive to therapy. Thus, blastema seems to play a central role in prognosis of Wilms' tumours; either reacting to therapy or, if insensitive, by metastasizing.
在患有肾母细胞瘤的儿童中，生存时间受到预防或控制转移性疾病是否成功的极大影响。当前的研究聚焦于与原发肿瘤相比转移灶的形态学方面。在8例患者中，似乎胚基是最有可能发生转移的成分，而转移灶中上皮和间质成分即使有也很少见。此外，对4例患者进行的流式细胞术DNA倍体测定显示，原发肿瘤和转移灶的干系均处于二倍体和低非整倍体（超二倍体）范围内。最后，分析了4例患者中治疗对原发肿瘤形态的影响。在这些病例中，胚基似乎是对治疗最敏感的成分。因此，胚基似乎在肾母细胞瘤的预后中起核心作用；要么对治疗产生反应，要么如果不敏感，则通过转移起作用。
