Konrad R M, Ammedick U, Haag H, Haesters R, Lemme J
Zentralbl Chir. 1987;112(3):157-65.
The high rate of locally delimited recurrences of parvicellular bronchial carcinoma, following chemotherapy and complete remission, primarily in cases of limited disease, prompted the authors to apply preoperative neoadjuvant chemotherapy to seven patients. Four of them were without tumours for six to 72 months from treatment. One patient died of myocardial infarction but with no tumour detectable 15 months after treatment. Locally delimited recurrence with additional lymphogenic spreading was recorded from one patient only. Two patients died of haematogenic metastasation. The concept should be tested for efficiency on larger groups of patients.
微小细胞支气管癌在化疗及完全缓解后，局部局限性复发率较高，主要见于疾病局限的病例，这促使作者对7例患者应用术前新辅助化疗。其中4例患者自治疗后6至72个月无肿瘤。1例患者死于心肌梗死，但治疗后15个月未检测到肿瘤。仅1例患者出现局部局限性复发并伴有额外的淋巴源性扩散。2例患者死于血行转移。该概念应在更大规模的患者群体中进行疗效测试。
