Sittenfeld Sarah M C, Suh John H, Murphy Erin S, Yu Jennifer S, Chao Samuel T
Department of Radiation Oncology, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, United States.
Front Oncol. 2018 Sep 24;8:385. doi: 10.3389/fonc.2018.00385. eCollection 2018.
Brain metastases remain the most common neurologic complication of cancer. With improvement in surveillance and systemic therapy, patients with limited CNS disease are living longer after diagnosis, thus influencing the importance of optimal radiation treatment in order to maximize local control and minimize morbidity. In patients with a limited number of brain metastases, stereotactic radiosurgery is more recently seen as an appropriate sole modality for management with excellent local control. As newer systemic therapies emerge and with the advent of immunotherapies and targeted therapies for metastatic CNS disease, further research is needed in the optimal timing and sequencing of these modalities.
脑转移瘤仍然是癌症最常见的神经系统并发症。随着监测和全身治疗的改善，中枢神经系统疾病局限的患者在诊断后存活时间更长，因此影响了优化放射治疗的重要性，以便最大限度地实现局部控制并将发病率降至最低。在脑转移瘤数量有限的患者中，立体定向放射外科最近被视为一种合适的单一治疗方式，具有出色的局部控制效果。随着更新的全身治疗方法的出现以及针对转移性中枢神经系统疾病的免疫疗法和靶向疗法的问世，需要对这些治疗方式的最佳时机和顺序进行进一步研究。
