Moriello K A, Halliwell R E, Oakes M
Am J Vet Res. 1987 Mar;48(3):459-62.
Changes in thyroxine (T4), triiodothyronine (T3), and cortisol during a combined adrenal (dexamethasone suppression/adrenocorticotrophic hormone response test) and thyroid function tests (thyroid-stimulating hormone [TSH] response test) were determined in 20 healthy hospitalized pet dogs. The effect of dexamethasone on T4 and T3 changes was evaluated during a simultaneous TSH response/dexamethasone suppression adrenocorticotrophic hormone response test. Greater ranges in basal cortisol concentrations and slower changes after dexamethasone was administered were observed in healthy pet dogs kenneled in a hospital setting than those reported for conditioned laboratory dogs. Pet dogs were observed to demonstrate cortisol suppression more reliably at 4 hours than at 2 hours after dexamethasone was administered. Dexamethasone had no effect on the response to TSH as assessed by T4 and T3 assays, thus supporting the validity of combining adrenal and thyroid response tests in a 5-hour period.
在20只健康的住院宠物狗中，测定了联合肾上腺（地塞米松抑制/促肾上腺皮质激素反应试验）和甲状腺功能试验（促甲状腺激素[TSH]反应试验）期间甲状腺素（T4）、三碘甲状腺原氨酸（T3）和皮质醇的变化。在同步TSH反应/地塞米松抑制促肾上腺皮质激素反应试验期间，评估了地塞米松对T4和T3变化的影响。与有条件的实验犬相比，在医院环境中饲养的健康宠物狗观察到基础皮质醇浓度范围更大，地塞米松给药后变化更慢。观察到宠物狗在地塞米松给药后4小时比2小时更可靠地表现出皮质醇抑制。通过T4和T3测定评估，地塞米松对TSH反应没有影响，因此支持在5小时内联合肾上腺和甲状腺反应试验的有效性。
