Department of Endocrinology, University Hospital of Bordeaux, Bordeaux, France.
Eur J Endocrinol. 2018 Oct 12;179(5):L1-L2. doi: 10.1530/EJE-18-0694.
We read with interest the paper of Young et al. in which the authors recommend avoiding ketoconazole in the treatment of Cushing’s syndrome when patients display increased liver enzymes (>2-fold the upper limit of normal (ULN)). We found in a small series of patients that We read with interest the paper of Young et al. in which the authors recommend avoiding ketoconazole in the treatment of Cushing’s syndrome when patients display increased liver enzymes (>2-fold the upper limit of normal (ULN)). Although limited, our experience suggests that liver function tests may improve during ketoconazole treatment and that, in a life-threatening situation such as severe Cushing’s syndrome, increased liver enzymes should not preclude ketoconazole prescription.
我们饶有兴趣地阅读了 Young 等人的论文，作者建议在患者出现肝酶升高（超过正常值上限的 2 倍）时避免使用酮康唑治疗库欣综合征。我们在一小系列患者中发现，尽管经验有限，但我们的经验表明，在使用酮康唑治疗期间肝功能检查可能会改善，并且在危及生命的情况下，如严重的库欣综合征，肝酶升高不应排除酮康唑的处方。
