Chen Chiao-Yun
Department and Graduate Institute of Criminology, National Chung Cheng University, Chiayi, Taiwan.
Neuroreport. 2018 Dec 5;29(17):1509-1515. doi: 10.1097/WNR.0000000000001144.
To investigate whether modulation of the excitability of the right ventrolateral prefrontal cortex (rVLPFC) using transcranial direct current stimulation (tDCS) would alter proactive aggression, reactive aggression, or both. The Taylor Aggression Paradigm, considered to provide measures indicative of the two types of aggression, was presented with delivery of either anodal tDCS or sham tDCS over rVLPFC. Participants were required to select levels of negative feedback to delivery should they win on a competitive reaction-time task and the levels selected on initial trials (with no feedback from the opponent) were taken as measures of proactive aggression, whereas levels on subsequent trials (with feedback from the opponent) were indicators of reactive aggression. The 'opponent' throughout was actually computer controlled. tDCS delivered over rVLPFC was associated with significantly lower levels of negative feedback being selected for both types of trials, suggesting reduction of proactive and reactive aggression. The results are consistent with rVLPFC playing a general role in the regulation of aggressive behavior. Further work to evaluate the site-related specificity of this would be beneficial.
为了研究使用经颅直流电刺激（tDCS）调节右侧腹外侧前额叶皮层（rVLPFC）的兴奋性是否会改变主动性攻击、反应性攻击或两者皆有。采用泰勒攻击范式，该范式被认为能够提供这两种攻击类型的指标，在rVLPFC上施加阳极tDCS或伪tDCS时呈现该范式。参与者需要在竞争性反应时任务中获胜时选择给予对方负面反馈的程度，初始试验（无对手反馈）时选择的程度作为主动性攻击的指标，而后续试验（有对手反馈）时的程度则是反应性攻击的指标。整个过程中的“对手”实际上是由计算机控制的。在rVLPFC上施加tDCS与两种试验中选择的负面反馈水平显著降低相关，这表明主动性攻击和反应性攻击均有所减少。结果表明rVLPFC在攻击行为调节中发挥着普遍作用。进一步评估其与部位相关的特异性的研究将是有益的。
