Chen Hui, Wang Huan, Yang Zhenglin
Ophthalmology Department.
Sichuan Provincial Key Laboratory for Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, P.R. of China.
Ophthalmic Plast Reconstr Surg. 2018 Nov/Dec;34(6):e184-e186. doi: 10.1097/IOP.0000000000001234.
Hyaluronic acid injection can lead to skin necrosis, visual loss, and other complications. The blindness with ophthalmoplegia and ptosis is a rare, but terrible and devastating complication. The disfigured appearance usually has significant impact on patient's social life. There is no standard treatment. A patient with hyaluronic acid induced blindness, ophthalmoplegia, and ptosis is reported. Six days after the onset, peribulbar/retrobulbar injections of high dosage hyaluronidase were performed. The orbital edema and ptosis immediately improved. The ophthalmoplegia and ptosis improved significantly within a month and resolved completely within 3 months, although the right vision remained blind. Peribulbar/retrobulbar injection of hyaluronidase is a potential rescue therapy for the hyaluronic acid induced ophthalmoplegia and ptosis.
透明质酸注射可导致皮肤坏死、视力丧失及其他并发症。伴有眼肌麻痹和上睑下垂的失明是一种罕见但严重且极具破坏性的并发症。毁容外观通常会对患者的社交生活产生重大影响。目前尚无标准治疗方法。本文报告了一名因透明质酸导致失明、眼肌麻痹和上睑下垂的患者。发病六天后，进行了球周/球后高剂量透明质酸酶注射。眶周水肿和上睑下垂立即得到改善。眼肌麻痹和上睑下垂在一个月内显著改善，并在三个月内完全消退，尽管右眼视力仍失明。球周/球后注射透明质酸酶是治疗透明质酸所致眼肌麻痹和上睑下垂的一种潜在挽救疗法。
