Meuleman N, Vercruyssen M
Service d'Hématologie, Institut Jules Bordet, ULB.
Rev Med Brux. 2018;39(4):302-306.
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic premalignant plasma cell disorder. MGUS is a common disorder and the diagnosis is often made accidentally when a protein electrophoresis is performed in a routine blood test or during a biological assessment for other conditions. In the absence of biological abnormalities or clinical symptoms suggesting a plasma or lymphoplasma-cell disorder, there is no indication for routine screening of the monoclonal protein. When MGUS is diagnosed, the risk of transformation into myeloma or other lymphoproliferative disorders is estimated at 1 % per year. MGUS can also be associated with diseases that are not malignant disorders and in some cases, the monoclonal gammopathy is the witness of another rare but severe disorder wich will be critical not to be missdiagnosed.
意义未明的单克隆丙种球蛋白病（MGUS）是一种无症状的癌前浆细胞疾病。MGUS是一种常见疾病，常在常规血液检查中进行蛋白电泳或对其他病症进行生物学评估时偶然做出诊断。在没有提示浆细胞或淋巴浆细胞疾病的生物学异常或临床症状时，没有常规筛查单克隆蛋白的指征。当诊断为MGUS时，每年转化为骨髓瘤或其他淋巴增殖性疾病的风险估计为1%。MGUS也可与非恶性疾病相关，在某些情况下，单克隆丙种球蛋白病是另一种罕见但严重疾病的表现，至关重要的是不要误诊。
