Oncol Res Treat. 2018;41(11):706-711. doi: 10.1159/000492341. Epub 2018 Oct 16.
Triple-negative breast cancer (TNBC) is a breast cancer subgroup that lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Certain magnetic resonance imaging (MRI) features of TNBC might reflect the poor prognosis of TNBC. Standardized uptake value (SUV) of [18F]fluorodeoxyglucose positron emission tomography/computed tomography is 1 of predictive prognostic factors for breast cancer. The purpose of this study was to correlate MRI features of TNBC with SUVmax to determine whether MRI findings in TNBC could be helpful for predicting prognosis.
We analyzed MRI findings of TNBC according to breast imaging reporting and data system (BI-RADS) MRI lexicon. We also assessed intratumoral high signal intensity on T2-weighted MRI, time-intensity curve analysis and peritumoral edema. The relationship between MRI features of TNBC and SUVmax was then statistically analyzed.
Significant correlations of SUVmax with the internal enhancement pattern, intratumoral high signal intensity on T2-weighted images, and peritumoral edema were noted. There was no significant correlation of SUVmax with mass shape, margin, or kinetics.
Certain MRI features of TNBC such as heterogeneous or rim enhancement, intratumoral very high signal intensity on T2 images, and peritumoral edema might be useful in predicting the prognosis of patients with TNBC.
三阴性乳腺癌（TNBC）是一种缺乏雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体 2（HER2）表达的乳腺癌亚组。TNBC 的某些磁共振成像（MRI）特征可能反映了 TNBC 的不良预后。[18F]氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的标准化摄取值（SUV）是预测乳腺癌的预后因素之一。本研究旨在探讨 TNBC 的 MRI 特征与 SUVmax 的相关性，以确定 TNBC 的 MRI 表现是否有助于预测预后。
我们根据乳腺影像报告和数据系统（BI-RADS）MRI 词汇分析了 TNBC 的 MRI 表现。我们还评估了 T2 加权 MRI 上的肿瘤内高信号强度、时间-强度曲线分析和肿瘤周围水肿。然后对 TNBC 的 MRI 特征与 SUVmax 之间的关系进行了统计学分析。
SUVmax 与内部增强模式、T2 加权图像上的肿瘤内高信号强度和肿瘤周围水肿之间存在显著相关性。SUVmax 与肿块形状、边界或动力学之间无显著相关性。
TNBC 的某些 MRI 特征，如不均匀或边缘增强、T2 图像上的肿瘤内极高信号强度和肿瘤周围水肿，可能有助于预测 TNBC 患者的预后。
