Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.01801-18. Print 2019 Jan.
The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant complex, , , and strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MICs against , , and were 1, 0.25, and 0.5 mg/liter, respectively. Against , the MIC was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.
头孢他啶-去铁胺的活性针对碳青霉烯类耐药的革兰氏阴性菌。在这项研究中，通过在缺铁 Mueller-Hinton 肉汤中的微量稀释法来确定头孢他啶-去铁胺对特征性碳青霉烯类耐药的 、 、 和 菌株的活性。对 、 、 和 的 MIC 分别为 1、0.25 和 0.5mg/l。对于携带 OXA-48 样、KPC-3 的组，头孢他啶-去铁胺的 MIC 分别为 1mg/l 和 2mg/l，对于携带 TEM/SHV ESBL、NDM 和 KPC-2 的组，MIC 为 8mg/l。
