钯催化芳烃与炔烃的C-H烯基化反应：通过1,4-氯迁移立体选择性合成氯乙烯
Palladium-Catalyzed C-H Alkenylation of Arenes with Alkynes: Stereoselective Synthesis of Vinyl Chlorides via a 1,4-Chlorine Migration.
作者信息
Li Zhen, Duan Wei-Liang
机构信息
College of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Road, Yangzhou, 225002, China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
出版信息
Angew Chem Int Ed Engl. 2018 Dec 3;57(49):16041-16045. doi: 10.1002/anie.201808866. Epub 2018 Nov 7.
PMID:30325097
Abstract
A directing group-free, ligand-promoted palladium-catalyzed C-H arylation of internal alkynes with simple arenes was developed. Alkenyl chlorides resulting from a 1,4-chlorine migration or trisubstituted alkenes were produced in moderate to good yields depending on the type of alkyne.
摘要
开发了一种无导向基团、配体促进的钯催化的内炔烃与简单芳烃的C-H芳基化反应。根据炔烃的类型，通过1,4-氯迁移产生的烯基氯或三取代烯烃的产率适中至良好。
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