Somasundaram Siva G, Muresanu Cristian, Schield Pamela, Makhmutovа Alfiya, Bovina Elena V, Fisenko Vladimir P, Hasanov Nusrat F, Aliev Gjumrakch
Departments of Biology & Health Education, Salem University, 223 West Main Street, Salem, WV 26426, United States.
NAFA LLC, 64 Carolina Ave, Salem, WV 26426, United States.
Cent Nerv Syst Agents Med Chem. 2019;19(1):8-14. doi: 10.2174/1871524918666181017152053.
The pathophysiology of the intervertebral discs plays a significant role in the people's life quality. There is not adequate research done in the pathogenesis and treatment of intervertebral disc degeneration. Alternately, self-educated physiology offers a novel and noninvasive method to reverse the degenerated discs. In this single case study, report attempts have been made to highlight the effect of the self-educative physiology, on magnetic resonance imaging investigations, of progressive healing, on the degenerated intervertebral discs. Based on this novel method, an effort has been made to review literature on the degeneration of intervertebral discs and available mode of treatments and then to propose a hypothesis for the biochemical mechanisms of healing. The idea is that transforming growth factor-β1 from seminal plasma secretions may contribute to releasing the osteogenic protein- 1 which induces nucleus pulposus and annulus fibrosus cells in intervertebral discs for repairs. In addition, the patient's medical history is presented with background information.
椎间盘的病理生理学在人们的生活质量中起着重要作用。目前对椎间盘退变的发病机制和治疗方法的研究还不够充分。相反，自我教育生理学提供了一种新颖且无创的方法来逆转退变的椎间盘。在这个单病例研究中，报告试图突出自我教育生理学对磁共振成像检查的影响，以及对退变椎间盘进行渐进性愈合的影响。基于这种新方法，努力回顾了关于椎间盘退变和现有治疗方式的文献，然后提出了愈合生化机制的假设。其观点是，精浆分泌物中的转化生长因子-β1可能有助于释放成骨蛋白-1，该蛋白可诱导椎间盘内的髓核和纤维环细胞进行修复。此外，还介绍了患者的病史及背景信息。
