心脏淋巴管在健康和疾病中的作用。

Cardiac lymphatics in health and disease.

机构信息

Normandy University, UniRouen, INSERM (Institut National de la Santé et de la Recherche Médicale) UMR1096 (EnVI Laboratory), FHU REMOD-VHF, Rouen, France.

Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland.

出版信息

Nat Rev Cardiol. 2019 Jan;16(1):56-68. doi: 10.1038/s41569-018-0087-8.

DOI:10.1038/s41569-018-0087-8

PMID:30333526

Abstract

The lymphatic vasculature, which accompanies the blood vasculature in most organs, is indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and nutritional lipid uptake and transport, as well as in reverse cholesterol transport. In this Review, we discuss the physiological role of the lymphatic system in the heart in the maintenance of cardiac health and describe alterations in lymphatic structure and function that occur in cardiovascular pathology, including atherosclerosis and myocardial infarction. We also briefly discuss the role that immune cells might have in the regulation of lymphatic growth (lymphangiogenesis) and function. Finally, we provide examples of how the cardiac lymphatics can be targeted therapeutically to restore lymphatic drainage in the heart to limit myocardial oedema and chronic inflammation.

摘要

淋巴系统伴随血液系统分布于大多数器官中，对于维持组织液的动态平衡、免疫细胞的迁移、营养脂质的摄取和运输以及胆固醇的逆向转运都至关重要。在这篇综述中，我们讨论了心脏中淋巴系统在维持心脏健康方面的生理作用，并描述了心血管疾病（包括动脉粥样硬化和心肌梗死）中发生的淋巴结构和功能的改变。我们还简要讨论了免疫细胞在调节淋巴生成（淋巴管生成）和功能方面可能发挥的作用。最后，我们提供了一些例子，说明了如何靶向心脏淋巴管以恢复心脏的淋巴引流，从而限制心肌水肿和慢性炎症。