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营养支持对原发性肺癌患者术后呼吸功能恢复的作用

Role of nutritional support for postoperative recovery of respiratory function in patients with primary lung cancer.

作者信息

Yang Jinhong, Zhang Qianqian, Wang Xiaoli

机构信息

Department of Medical Oncology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.

Department of Radiotherapy, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.

出版信息

Oncol Lett. 2018 Nov;16(5):5978-5982. doi: 10.3892/ol.2018.9348. Epub 2018 Aug 22.

Abstract

This study explored the role of nutritional support for postoperative recovery of respiratory function in patients with primary lung cancer. Clinical data of 182 patients with primary lung cancer who were admitted to Weifang People's Hospital from January 2013 to December 2015 and underwent lung cancer surgery, were collected and retrospectively analyzed. According to the postoperative diet plan, patients were divided into two groups: General diet group (n=80) and nutrition therapy group (n=102). Patients in the general diet group were given a general diet without any nutritional instruction, whereas the patients in the nutrition therapy group were given an enteral nutritional supplement in addition to a general diet. The changes of nutritional indices, recovery status of respiratory function and incidence of adverse events for patients in the two groups were observed, and the data were analyzed statistically. At day 14 after the therapy started, the body mass index, mid-arm circumference and triceps skinfold of patients in the nutrition therapy group were significantly better than those in the general diet group (P<0.05). More significant improvements in levels of hemoglobin, serum albumin and prealbumin were observed in the nutrition therapy group, and the differences in comparison with levels in the general diet group were statistically significant (P<0.05). The respiratory function was more significantly improved for patients in the nutrition therapy group as well, compared to patients in the general diet group (P<0.05). At the end of 1-year follow-up, incidences of malnutrition, lung infection and mortality in the nutrition therapy group were lower than that of the general diet group (P<0.05). The positive impact of appropriate nutritional support on recovery of postoperative respiratory function improved overall outcomes of patients with lung cancer and reduced mortality as well. The nutrition therapy is worth further clinical study.

摘要

本研究探讨了营养支持对原发性肺癌患者术后呼吸功能恢复的作用。收集了2013年1月至2015年12月在潍坊市人民医院住院并接受肺癌手术的182例原发性肺癌患者的临床资料,并进行回顾性分析。根据术后饮食计划,将患者分为两组:普通饮食组(n = 80)和营养治疗组(n = 102)。普通饮食组患者给予无任何营养指导的普通饮食,而营养治疗组患者在普通饮食的基础上给予肠内营养补充剂。观察两组患者营养指标的变化、呼吸功能恢复情况及不良事件发生率,并对数据进行统计学分析。治疗开始后第14天,营养治疗组患者的体重指数、上臂中部周长和三头肌皮褶厚度均显著优于普通饮食组(P < 0.05)。营养治疗组患者的血红蛋白、血清白蛋白和前白蛋白水平改善更显著,与普通饮食组水平相比差异有统计学意义(P < 0.05)。营养治疗组患者的呼吸功能改善也比普通饮食组更显著(P < 0.05)。在1年随访结束时,营养治疗组的营养不良、肺部感染和死亡率低于普通饮食组(P < 0.05)。适当的营养支持对术后呼吸功能恢复具有积极影响,可改善肺癌患者的总体预后并降低死亡率。营养治疗值得进一步临床研究。

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