Shimura Tatsuo, Shibata Masahiko, Gonda Kenji, Kofunato Yasuhide, Ishigame Teruhide, Okada Ryo, Sato Naoya, Kimura Takashi, Kenjo Akira, Marubashi Shigeru
Department of Hepato-Biliary-Pancreatic and Transplant Surgery, Fukushima Medical University, Fukushima 960-1259, Japan.
Department of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1259, Japan.
Oncol Lett. 2018 Nov;16(5):6013-6018. doi: 10.3892/ol.2018.9367. Epub 2018 Aug 24.
The identification of novel biomarkers for hepatocellular carcinoma (HCC) is of great importance in improving the outcome of patients with HCC. The present study aimed to determine the prognostic significance of the soluble intercellular adhesion molecule (sICAM)-1 in patients with HCC. The present study prospectively collected clinicopathological data from 36 patients with HCC who had undergone successful hepatectomy. An analysis using a receiver operating characteristic (ROC) curve was performed to determine the cut-off value for predicting prognosis. Overall survival (OS), recurrence-free survival (RFS) and potential prognostic factors were analyzed. The ROC curve analysis revealed a sICAM-1 cut-off value of 440 ng/ml. HCC patients with sICAM-1 ≥440 ng/ml exhibited a poorer OS and RFS than those with sICAM-1 <440 ng/ml (P=0.002). sICAM-1 ≥440 ng/ml (hazard ratio=3.623; 95% confidence interval: 1.145-11.458; P=0.028) and Child B (hazard ratio=1.514; 95% confidence interval: 1.066-2.150; P=0.021) were independent prognostic factors for OS, and sICAM-1 ≥440 ng/ml was an independent prognostic factor for RFS (hazard ratio=3.625; 95% confidence interval: 1.233-10.659; P=0.019). Serum sICAM-1 may be a promising predictor for the overall and recurrence-free survival of patients with HCC.
鉴定肝细胞癌（HCC）的新型生物标志物对于改善HCC患者的预后至关重要。本研究旨在确定可溶性细胞间黏附分子（sICAM）-1在HCC患者中的预后意义。本研究前瞻性收集了36例成功接受肝切除术的HCC患者的临床病理数据。采用受试者工作特征（ROC）曲线分析来确定预测预后的临界值。分析了总生存期（OS）、无复发生存期（RFS）及潜在预后因素。ROC曲线分析显示sICAM-1的临界值为440 ng/ml。sICAM-1≥440 ng/ml的HCC患者的OS和RFS较sICAM-1<440 ng/ml的患者更差（P=0.002）。sICAM-1≥440 ng/ml（风险比=3.623；95%置信区间：1.145-11.458；P=0.028）和Child B级（风险比=1.514；95%置信区间：1.066-2.150；P=0.021）是OS的独立预后因素，sICAM-1≥440 ng/ml是RFS的独立预后因素（风险比=3.625；95%置信区间：1.233-10.659；P=0.019）。血清sICAM-1可能是HCC患者总生存期和无复发生存期的一个有前景的预测指标。
