铜催化的 3-(2-碘苯基)-1-芳基-1-丙酮和硫化钾在有氧条件下合成 2-酰基苯并[b]噻吩。
Copper-catalyzed synthesis of 2-acylbenzo[b]thiophenes from 3-(2-iodophenyl)-1-arylpropan-1-ones and potassium sulfide under aerobic conditions.
机构信息
National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, Hunan Normal University, Changsha, Hunan 410081, China.
出版信息
Org Biomol Chem. 2018 Nov 7;16(43):8020-8024. doi: 10.1039/c8ob02315h.
A method was developed for the synthesis of 2-acylbenzo[b]thiophenes via a copper-catalyzed sulfuration of 3-(2-iodophenyl)-1-arylpropan-1-ones with K2S under aerobic conditions. Mechanistically, this procedure was proved to involve the formation of a dihydrobenzo[b]thiophene intermediate.
一种通过在有氧条件下用 K2S 催化 3-(2-碘苯基)-1-芳基-1-丙酮与铜进行硫化来合成 2-酰基苯并[b]噻吩的方法被开发出来。从机理上看，该过程被证明涉及到二氢苯并[b]噻吩中间体的形成。
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