IEEE J Biomed Health Inform. 2019 Sep;23(5):1952-1963. doi: 10.1109/JBHI.2018.2876087. Epub 2018 Oct 15.
For many cerebrovascular diseases both blood pressure (BP) and hemodynamic changes are important clinical variables. In this paper, we describe the development of a novel approach to noninvasively and simultaneously monitor cerebral hemodynamics, BP, and other important parameters at high temporal resolution (250 Hz sampling rate). In this approach, cerebral hemodynamics are acquired using near infrared spectroscopy based sensors and algorithms, whereas continuous BP is acquired by superficial temporal artery tonometry with pulse transit time based drift correction. The sensors, monitoring system, and data analysis algorithms used in the prototype for this approach are reported in detail in this paper. Preliminary performance tests demonstrated that we were able to simultaneously and noninvasively record and reveal cerebral hemodynamics and BP during people's daily activity. As examples, we report dynamic cerebral hemodynamic and BP fluctuations during postural changes and micturition. These preliminary results demonstrate the feasibility of our approach, and its unique power in catching hemodynamics and BP fluctuations during transient symptoms (such as syncope) and revealing the dynamic features of related events.
对于许多脑血管疾病，血压（BP）和血液动力学变化都是重要的临床变量。在本文中，我们描述了一种新的方法，该方法可以非侵入性地同时监测大脑血液动力学、BP 和其他重要参数，具有高时间分辨率（250Hz 采样率）。在这种方法中，使用近红外光谱传感器和算法来获取大脑血液动力学，而使用颞浅动脉张力测量法通过脉搏传输时间进行连续 BP 测量，并进行漂移校正。本文详细介绍了该方法原型中使用的传感器、监测系统和数据分析算法。初步性能测试表明，我们能够在人们的日常活动中同时非侵入性地记录和揭示大脑血液动力学和 BP。作为示例，我们报告了在姿势变化和排尿过程中动态的大脑血液动力学和 BP 波动。这些初步结果证明了我们方法的可行性，以及它在捕捉短暂症状（如晕厥）期间的血液动力学和 BP 波动以及揭示相关事件的动态特征方面的独特优势。
