Ditter S M, Mirra S S
Neurology. 1987 May;37(5):754-60. doi: 10.1212/wnl.37.5.754.
While dementia in Parkinson's disease (PD) is well described, PD features in Alzheimer's disease (AD) are being increasingly recognized. In 20 neuropathologically confirmed AD brains, 11 cases (55%) showed PD changes (Lewy body formation, neuronal loss, and gliosis of pigmented nuclei), with no significant difference in age or symptom duration between those cases with and without PD pathology. A history of rigidity in the absence of neuroleptic medication was noted in 80% of those with PD pathology but only 14% of those without PD pathology. Tremor was not observed in either group. This suggests that extrapyramidal signs, especially rigidity, noted in many AD patients are related to coexistent PD pathology.
虽然帕金森病（PD）中的痴呆已被充分描述，但阿尔茨海默病（AD）中的PD特征也越来越受到认可。在20例经神经病理学确诊的AD大脑中，11例（55%）出现了PD改变（路易小体形成、神经元丢失和色素核胶质增生），有和没有PD病理学改变的病例在年龄或症状持续时间上无显著差异。在有PD病理学改变的患者中，80%有在无抗精神病药物情况下出现强直的病史，而在无PD病理学改变的患者中这一比例仅为14%。两组均未观察到震颤。这表明在许多AD患者中 noted的锥体外系体征，尤其是强直，与共存的PD病理学改变有关。
